Complement Activation in Chromosome 13 Dementias

Complement Activation in Chromosome 13 Dementias

From the Departments of ‡Pathology and §§Psychiatry, School of Medicine, New York University, New York, New York 10016, the ¶Queen Square Brain Bank and Department of Molecular Pathogenesis, Division of Neuropathology, Institute of Neurology, University College of London, London WCIN3BG, United Kingdom, the Departments of Neurology and ‡‡Neuropathology, Århus University Hospital, Århus DK8000, ...

Complement activation in uveitis.

To determine whether complement is activated in uveitis we have measured plasma levels of C3d, a sensitive indicator of complement activation. Increased levels of C3d were found in 11 of 15 patients with idiopathic uveitis, 13 of whom had circulating immune complexes containing complement components. Since during complement activation potent mediators of inflammation are generated, it is sugges...

Complement Activation

The complement system is the most important biochemical cascade in the blood for the recognition, opsonization, and elimination of foreign materials. To date, the leading causes of death in the United States include cancer, cardiovascular and neurodegenerative diseases, and diabetes. New treatments are urgently needed to treat these devastating diseases and nanotechnology potentially provides n...

X-Chromosome Complement and Estrogen

Non-disjunction of chromosome 13.

We performed a molecular study with 21 microsatellites on a sample of 82 trisomy 13 conceptuses, the largest number of cases studied to date. The parental origin was determined in every case and in 89% the extra chromosome 13 was of maternal origin with an almost equal number of maternal MI and MII errors. The latter finding is unique among human autosomal trisomies, where maternal MI (trisomie...